Introduzzjoni għal drogi konjittivi idra-21

Idra-21 Trab konjittivhuwa regolatur allosteriku pożittiv tar-riċettur AMPA u derivattiv tal-benzothiadiazole. Hija molekula kirali li fiha ( plus ) - IDRA-21 hija l-forma attiva.

Kif ġab ruħu l-IDRA-21 f'esperimenti fuq l-annimali?

Fl-istudju tal-promozzjoni tal-intelliġenza fl-annimali,Trab IDRA-21tejbet b'mod sinifikanti l-abbiltà tat-tagħlim u l-memorja. Fit-treġġigħ lura tad-defiċits konjittivi ikkawżati minn użu fit-tul-alprazolam jew scopolamine, huwa madwar 10-30 darba aktar b'saħħtu minn aniracetam. L-iktar ħaġa tal-għaġeb hija l-ħin tal-metaboliżmu tad-droga tiegħu: ġie studjat biex jipproduċi effetti sostnuti li jdumu sa 48 siegħa wara amministrazzjoni waħda. Ir-riċerkaturi jgħidu li l-mekkaniżmu ta 'dan l-effett x'aktarx ikun permezz tal-promozzjoni ta' titjib fit-tul bejn is-sinapsi tal-moħħ.

X'inhu l-proċess ta 'esplorazzjoni tad-droga ta' titjib konjittiv? Kif kienIDRA-21imwieled?

In 1990, neuroscientist Eric Kandel discovered a brain chemical called cyclic adenosine monophosphate response element-binding protein (CREB), which is a key factor in memory formation. In 1994, neuroscientists Tim Tully and Jerry Yin adjusted the way CREB works in a fruit fly. When learning new habits, fruit flies with enhanced CREB were 10 times faster than their unchanged counterparts. Later, other researchers got the same results in mice. In 1999, Qian Zhuo, a neuroscientist at Princeton University, created a mouse with more pairs of NR2B genes, which can coordinate the activity of synaptic receptors in the brain. In memory and learning tests, NR2B enhanced mice performed five times better than unmodified mice. After 2000, many new pharmaceutical companies competed to apply these findings to humans. Both memory pharmaceutical and helikongshan medical are conducting clinical trials of drugs related to CREB. Another COLTEX pharmaceutical company is developing a brain chemical called ampakine to achieve similar effects through another neural pathway. Among so many research institutions, Jingsi pharmaceutical （Abbreviation: IDRA） has developed IDRA-21 through step-by-step analogy research. At the same time, there are many sister products of this product, which have been eliminated for various reasons.